Category: News

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Wednesday, March 9, 2022
4:00-5:00pm PST

Alzheimer’s disease is a common form of dementia that leads to devastating cognitive and neurological deficits. However, despite affecting an estimated 6.2 million adults in the US alone in 2021, its causes are poorly understood and no effective treatments exist to halt or reverse the neuron death caused by the disease. How the disease starts — and what happens in single cells across the brain as the disease progresses — is similarly unknown. Research at the Allen Institute for Brain Science and elsewhere on the types of cells that make up the human brain has applications for understanding what is happening in Alzheimer’s.

ISCRM faculty members Jessica Young, Sumie Jayadev, and Christine Disteche have received a five-year, $6 million R01 grant to study the mechanisms of sex differences in risk of developing Alzheimer’s disease. The researchers will use unique hiPSC lines generated by the Disteche lab that have different numbers of sex chromosomes and generate matched APOE4 or APOE3 (a non-risk version of the gene) using CRISPR. Neural differentiation protocols generated in the Young lab will be used to derive neurons, glia, and brain organoids for single cell gene expression and functional analyses. The Jayadev lab will take the lead on performing single-nucleus RNA sequencing and immune cell phenotyping in male and female brains with APOE4 and APOE3 genotypes to define the molecular pathways that contribute to sex differences in AD. Co-investigators on the project include C. Dirk Keene, ISCRM affiliate and leader of the UW Neuropathology Core, and Joel Berletch, ISCRM investigator and Research Assistant Professor in Laboratory Medicine and Pathology.

This year’s virtual conference, to be held November 4th – 6th, 2021, will focus on the theme of Taking Flight, celebrating the new society and highlighting the promise of this emerging field. We have an international and all-star lineup of speakers! Receive up to 15.25 AMA PRA Category 1 Credits™. There is NO Fee to attend.

The conference will offer attendees the ability to learn from experts in the world of neuropalliative care, hear updates in practice patterns, review the state of the science in neuropalliative care, and network with others who are interested in the field.

Invite your colleagues and friends to attend! Everyone involved with or affected by neurologic illness is welcome at the INPCS Annual Meeting. Please share the news with your connections about this free and virtual meeting.
Support INPCS! Although the meeting is free to attend it was not free to put together. Consider making a donation to the Society. No matter the amount, your donation makes a difference, will be used to further our mission (including future meetings) and is tax deductible.

INPCS is also seeking Annual Meeting and Year-Round sponsors. If you have connections with potential sponsors (e.g. pharmaceuticals, disease foundations, philanthropic foundations), please let them know about this opportunity to support a great cause and connect to an amazing community (see prospectus below). If you have potential interest or questions please email Candace at info@inpcs.org

Can’t attend the meeting live? All topics will be recorded and available to view on our website at your leisure.
For additional information about the meeting or supporting the Society, please go to:
http://www.inpcs.org/2021AnnualMeeting

Watch the video by following the link below:https://www.today.com/video/transplant-recipient-meets-her-donor-for-1st-time-live-on-today-120034885810 For more information about Annette Wundes, MD, read her UW Medicine Biography:

The Carter Award, one of the AAN’s premier lectures, is given annually to an exceptional child neurologist. The Carter Lecture is scheduled for presentation at the AAN Annual Meeting during the Presidential Plenary Session on Sunday, April 3, 2022, at the Washington State Convention Center in Seattle, WA.

Doximity just released its rankings of Child Neurology residency programs and the University of Washington is ranked #9 among pediatric hospitals.

The 8th Annual Trainee Research Poster symposium was another great success and exhibition of the important work our trainees are producing. All the participants did a wonderful job presenting the work they are contributing to our field. Four candidates stood out among their peers. On behalf of our esteemed Dr. Leslie-Mawzi, Dr. Patel, Dr. Chamberlain, and Dr. Illith, it is the pleasure of Neurology Day Committee to announce four winners of the resident poster award this year.

Clinical Sciences

First Prize: Jennifer Keene
Optimized Benzodiazepine Treatment of Status Epilepticus through Emergency Medical Team Training
Authors: Jennifer C. Keene MD MBA, Brandon Woods MD MS, Mark Wainwright MD PhD, Mary King MD, Lindsey A. Morgan MD

Second Prize: Rachael Schutz
Early Withdrawal Of Life Sustaining Treatment After Mechanical Thrombectomy: A Mixed-Methods Analysis
Authors: Amita Singh, Rachael Schutz, Amber Ruiz, William Lou, Claire J Creutzfeldt, and Sandeep Khot

Basic Sciences

First Prize: Katherine E. Prater
Microglia subtypes in Alzheimer’s Disease detected by isolation of PU.1 positive nuclei from post-mortem human brain
Authors: Katherine E. Prater, Kevin J. Green, Carole L. Smith, Ali Shojaie, Wei Sun, Laura Heath, Shannon Rose, C. Dirk Keene, Jessica E. Young, Benjamin Logsdon, Gwenn A. Garden, and Suman Jayadev

Second prize: Ashley McDonough
CSF1R antagonism abolishes ischemic preconditioning mediated protection in white matter
Authors: Ashley McDonough, Margaret A Hamner, Davin C Gong, Sibylle Hodecker, Levi J Todd, German Rojas, Cara Nielson, Christopher B Ransom, Thomas A Reh, Bruce R Ransom, Jonathan R Weinstein
Congratulations to our winners and thank you to all who participated!